GLP1-R
GLP1-R is a pre-filled research pen containing a synthetic glucagon-like peptide-1 (GLP-1) receptor agonist analog, 4113.6 g/mol. GLP-1 is an intestinal incretin hormone; long-acting analogs are studied for receptor signalling, insulin secretion, glucose regulation and appetite pathways in laboratory and clinical-pharmacology research. Supplied at 40 mg, ≥99% purity by HPLC/MS, with a batch-specific COA. Research use only — not a drug product.
- Class: GLP-1 receptor agonist analog · 4113.6 g/mol
- Format: pre-filled research pen — no reconstitution
- Research contexts in the literature: GLP-1 receptor mechanism, incretin physiology, anti-inflammatory signalling, receptor crosstalk with GIP
- Documentation: independent HPLC/MS test, batch-specific COA in every order
- Not a pharmaceutical: research reagent only, not for human or animal use
- Research category
- Metabolic
- Formula / short form
- GLP-1 analog
- Molecular weight
- 4113.6 g/mol
- Quantity per pen
- 40 mg
- Purity
- ≥99% (HPLC/MS, per-lot COA)
- Test method
- HPLC / MS
- Form
- Pre-filled research pen
- Documentation
- Batch-specific COA ships with every order
What is a GLP-1 receptor agonist?
Glucagon-like peptide-1 is a 30-amino-acid hormone released by intestinal L-cells after food intake. It acts on the GLP-1 receptor to potentiate glucose-dependent insulin secretion, and native GLP-1 is degraded by DPP-IV within minutes. Synthetic analogs with substitutions and fatty-acid side chains extend that half-life from minutes to days, and it is those long-acting analogs that dominate current research. GLP1-R supplies one such analog in a research format.
What are GLP-1 analogs studied for in research?
- Mechanism of action. Drucker's 2018 *Cell Metabolism* review is the standard reference for GLP-1 receptor mechanisms and applications [1]; Holst's *Physiological Reviews* article covers the underlying physiology [2], updated in a 2026 review of proglucagon-derived peptides [3].
- Receptor crosstalk. GLP-1R and GIPR signalling interactions are an active area [4] — see the dual-agonist comparison.
- Anti-inflammatory signalling. A 2025 *J Clin Invest* review examines actions beyond metabolic endpoints [5].
These describe the research and clinical-pharmacology literature on GLP-1 analogs as a class. The research-grade material sold here is not a drug and is not for human use.
GLP1-R vs GLP1-T
GLP1-R is a single-receptor (GLP-1R) agonist; GLP1-T is a dual GLP-1/GIP receptor agonist. Read GLP-1 vs GLP-1/GIP dual agonist research.
Specifications and documentation
Identity by mass spectrometry (expected 4113.6 g/mol), purity by HPLC, batch-specific COA in every order. Store refrigerated and away from light, capped between uses. How to read the COA →
GLP1-R — frequently asked
What is GLP1-R?⌄
Is this the same as a prescription GLP-1 medication?⌄
What is the difference between GLP1-R and GLP1-T?⌄
Further reading
- GLP-1 vs GLP-1/GIP Dual Agonist Research: What the GIP Receptor Adds — Single-receptor incretin agonism has a two-decade literature; dual agonism has rewritten part of it in five years. Here is the comparison for researchers.
- How to Store Research Peptides: Lyophilized, Reconstituted and Pre-Filled — Peptides degrade by hydrolysis, oxidation and aggregation. Cold, dark and dry slow all three. The practical rules, by format.
- Lyophilized Vial vs Pre-Filled Pen: Choosing a Research Format — Nine catalog compounds ship as vials, five as pens. The choice is about flexibility versus consistency, not quality.
References
Published research cited for context only. Citing a study does not imply APX Labs product was used in it, and is not a claim of any effect.
- Drucker DJ (2018). Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. Cell Metab. PubMed ↗
- Holst JJ (2007). The physiology of glucagon-like peptide 1. Physiol Rev. PubMed ↗
- Gasbjerg LS, et al. (2026). Proglucagon-derived peptides: human physiology and therapeutic potential. Physiol Rev. PubMed ↗
- Lindquist P, Hoegen Dijkhof LR, Drzazga AK et al. (2026). GLP-1R and GIPR crosstalk modulates insulinotropic signaling pathways. Cell Chem Biol. PubMed ↗
- Wong CK, Drucker DJ (2025). Antiinflammatory actions of glucagon-like peptide-1-based therapies beyond metabolic benefits. J Clin Invest. PubMed ↗
What is GLP1-R studied for?
Widely referenced in metabolic research for its studied effect on GLP-1 receptor signalling, glucose regulation, and appetite pathways.
Handling & storage
Ships pre-filled — no reconstitution required. Store refrigerated and away from light; keep capped between uses and use within the window documented on the COA.
Research use only
Sold strictly for laboratory and research purposes. Not for human or veterinary use, and not intended to diagnose, treat, cure, or prevent any disease. Not evaluated by the FDA. Read the policy → · What RUO means →
Ready to start your research?
Third-party tested. COA-backed. Shipped discreetly. For research use only.